What is Spravato?
Spravato® is a prescription nasal spray that contains esketamine, a medication derived from ketamine used to treat certain forms of severe depression. Unlike traditional antidepressants that mainly affect serotonin and may take weeks to work, esketamine targets different brain receptors involved in mood regulation and neural communication. By acting on these pathways, Spravato® helps improve brain signaling and may provide relief for individuals who have not responded to standard antidepressant medications.
This treatment is approved for adults living with treatment-resistant depression or major depressive disorder with suicidal thoughts, particularly when other therapies have not been effective. Because of its specialized nature, Spravato® is administered only in a certified medical setting under professional supervision, where patients are monitored during each treatment session.
How SPRAVATO® Works in the Brain
Understanding how esketamine interacts with brain chemistry to provide rapid relief for treatment-resistant depression.
Targets Different Brain Receptors
Spravato® targets NMDA receptors in the brain involved in mood regulation, working differently from traditional antidepressants.
Activates the Glutamate System
Spravato® helps increase glutamate activity, an important brain chemical that supports communication between nerve cells.
Supports New Neural Connections
Glutamate activity encourages the brain to form new neural connections, restoring healthier mood and emotional balance.
Improves Depression Symptoms
By strengthening brain pathways, Spravato® may reduce symptoms of treatment-resistant depression rapidly.
Who Can Benefit From Spravato?
Spravato® may benefit adults who continue to experience depression even after trying standard antidepressant medications. This treatment offers an alternative approach for individuals seeking advanced care for severe or persistent depressive symptoms.People who may benefit from Spravato® therapy include:
- Adults with Treatment-Resistant Depression (TRD) who have not responded to multiple antidepressants.
- Individuals diagnosed with Major Depressive Disorder (MDD) with ongoing symptoms.
- Patients who may need a faster-acting treatment option than traditional medications.
- Adults experiencing depression with suicidal thoughts who require monitored clinical care.
- Individuals whose depression continues to affect daily life and overall well-being.
What to Expect During SPRAVATO Treatment
Comprehensive Evaluation
A clinician reviews your medical history, current medications, and prior treatments to determine whether SPRAVATO is appropriate for you.
Insurance Verification
Our staff reviews your insurance benefits and explores financial assistance options if needed.
Initial Treatment Phase
Patients typically receive SPRAVATO twice weekly for the first four weeks while being monitored in the clinic.
Observation Period
Each visit includes approximately two hours of post-treatment monitoring to ensure safety.
Maintenance Treatment
Once improvement is achieved, the frequency of treatments is gradually reduced based on your individualized care plan.
Am I a Candidate for Spravato®?
Spravato® therapy may be an option for adults who continue to struggle with depression despite trying traditional treatments. If standard antidepressants have not provided enough relief, this treatment may help address symptoms through a different brain pathway. A psychiatric evaluation is usually required to determine if Spravato® is an appropriate option for your condition.You may be a candidate for Spravato® treatment if you:
- Are 18 years or older and diagnosed with Major Depressive Disorder (MDD)
- Have tried two or more antidepressants without significant improvement
- Are currently taking an oral antidepressant alongside Spravato®
- Experience persistent depressive symptoms or suicidal thoughts requiring advanced care
Contact Our Office to Learn More About Spravato
Spravato treatment in Richardson at Premier Pain Centers & Premier Psychiatry offers a new path forward for individuals struggling with treatment-resistant depression. This advanced therapy works differently from traditional medications and is administered under careful medical supervision for patient safety and comfort. Take the next step toward better mental health by connecting with our team today.
Schedule an appointment with Premier Pain Centers & Premier Psychiatry today and start your journey toward renewed mental wellness.
469-562-4188Book Appointment →